Expressing exogenous functional odorant receptors in cultured olfactory sensory neurons
نویسندگان
چکیده
منابع مشابه
Spontaneous and sensory-evoked activity in mouse olfactory sensory neurons with defined odorant receptors.
Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in establishing proper synaptic connections and may also increase the sensitivity of the cells. Howev...
متن کاملSpontaneous and Sensory - evoked Activity in Mouse Olfactory Sensory 1 Neurons with Defined Odorant Receptors
24 25 Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the 26 olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the 27 type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in 28 establishing proper synaptic connections and may also increase the sensitivity of t...
متن کاملOdorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice.
A glomerulus in the mammalian olfactory bulb receives axonal inputs from olfactory sensory neurons (OSNs) that express the same odorant receptor (OR). Glomeruli are generally thought to represent functional units of olfactory coding, but there are no data on the electrophysiological properties of OSNs that express the same endogenous OR. Here, using patch clamp recordings in an intact epithelia...
متن کاملG protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons.
Mechanosensitive cells are essential for organisms to sense the external and internal environments, and a variety of molecules have been implicated as mechanical sensors. Here we report that odorant receptors (ORs), a large family of G protein-coupled receptors, underlie the responses to both chemical and mechanical stimuli in mouse olfactory sensory neurons (OSNs). Genetic ablation of key sign...
متن کاملExpression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice.
The sense of smell deteriorates in normal aging, but the underling mechanisms are still elusive. Here we investigated age-related alterations in expression patterns of odorant receptor (OR) genes and functional properties of olfactory sensory neurons (OSNs)-2 critical factors that define the odor detection threshold in the olfactory epithelium. Using in situ hybridization for 9 representative O...
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ژورنال
عنوان ژورنال: Neural Development
سال: 2008
ISSN: 1749-8104
DOI: 10.1186/1749-8104-3-22